babycord-one-years-stemmatch-combo-product

It’s not just your baby you’re blessed with but also with what comes attached with it as it could be the lifeline for a loved one who could be in need of stem cells for transplant

• What's Included?
  Banking of the baby's umbilical cord blood comes packaged as a comprehensive service covering all aspects right from collection until preservation and even release so that you can sit back and focus on your pregnancy and the following parenthood.

  Umbilical Cord Blood Collection

  Kit components are placed inside a vacuum insulated double walled stainless steel box to provide adequate temperature control and protection from physical damage

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  24/7 availability of trained paramedics ready for immediate dispatch, to assist your Ob / Gyn for umbilical cord blood collection, if requested (requires prior notice of 4 hours for collections within 50km of LifeCell service centre or not less than 8 hours for longer distance collection)

  Note: Kit box to be carried by customer to the hospital at the time of delivery and handed over to hospital nursing staff

  Shipment

  Includes onward and return free shipment of kit box. Express shipment possible for near term delivery or emergency collection

  Also includes free worldwide cryogenic transport of preserved sample for medical use

  Processing & Testing

  USFDA 510k approved reagent (PrepaCyte CB® from CryoCell International) utilised for separation of blood components to obtain high stem cell yields whilst removing 99% of red cell contaminants

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  Pre-storage testing for all samples includes assessment of Cellular Health (Cell Counts & Viability), Microbial Contamination (Bacterial & Fungal), Infectious Diseases (HIV, HBV, HTLV, HCV, Malaria, CMV), and Blood Grouping. For samples qualifying for community use additional testing includes HLA typing, CFU testing, and screening of Hemoglobinopathies

  Pre-transplant release criteria includes screening of 1200+ inherited genetic disorders through Genomescope

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  Preservation

  Samples preserved in vapour phase liquid nitrogen within stainless steel cryotanks at either of LifeCell’s cryostorage facilities (Chennai & Gurugram)

  Live Tracking available through customer portal to view temperature maintenance of respective cryotanks in which units are preserved

  As there is no expiry date on how long stem cells can be preserved you can also choose to opt for prepaid storage plans of 21 years to 75 years

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  Finding a Matched Unit

  LifeCell’s inventory of >60,000 qualified units available for matching within the community registry is largest in the country, thereby providing highest chances (>97%) of finding a suitably matched unit

  Free search for matching stem cells within LifeCell Community Inventory (StemMatch) & also within other registries worldwide.

  Learn More

  Release for Transplant

  Matching units are available for withdrawal for baby who’s sample is preserved plus siblings, parent’s and grandparents (maternal and paternal)

  Unlimited number of matching units can be withdrawn during the term of the agreement

  Release subject to usage in treatment of approved indications and registered clinical trials

  Learn More

  Medical Insurance and Add Ons

  LifeCell has partnered with third-party insurance companies to cover the cost of transplant related expenses for approved indications upto ₹20 lakhs.

  Upto 1 billion Mesenchymal Stem Cells and 20 lakhs financial assistance will be made available for free when used in approved indications

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  Receive upto 2 free placental tissue products (Allografts) that can be used in the treatment of wounds, when you donate your baby’s placenta

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  Family Floater

  Extend access to LifeCell’s community inventory to your other family members who may not be automatically covered under the program

  Extension can be granted to siblings of parents and comes at an additional price per person

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• Why Preserve?
  Banking of the baby's umbilical cord blood comes packaged as a comprehensive service covering all aspects right from collection until preservation and even release so that you can sit back and focus on your pregnancy and the following parenthood.

  Significant Need for Stem Cells

  Below is the risk of an individual being diagnosed of common blood cancers at some point in a lifetime*:

  • Leukemia: 1 in 62
  • Non-Hodgkin Lymphoma: 1 in 48
  • Myeloma: 1 in 125

  India has a high burden of inherited red cell diseases such as Thalassemia & Sickle Cell Disease (2.5 Lakh patients) where stem cell transplant is the only curative treatment option

  *As per National Cancer Institute, Surveillance, Epidemiology, and End Results Program

  Know More

  Cord is Easier to Match

  For stem cell matching there are between 6-10 parameters that need to be matched, with each parameter having between 2000-4000 variants.

  Adult bone marrow requires 9-10 parameters to be matched.

  However Umbilical Cord Blood requires only 6-8 parameters to be matched thereby making it 10-100x more easier to find a match.

  Learn More

  Ready Availability & No Additional Cost

  Umbilical Cord blood stem cells being frozen are 100% available and ready for immediate release. Further withdrawal of matching units from the community inventory is totally free

  Even in advanced countries like the US about 50% of registered adult donors back out at the time of medical need. Also some of this requires the donor to travel and there could be delays in access. Further there are significant costs in making arrangements for sourcing these cells

  Recommended by Experts

  Community cord blood banking has the benefits of both private banking and public banking and hence is a superior option

  Know More

  No wonder it’s supported by leading medical experts unlike private banking which has been criticised as inherited disorders make it unfit for baby’s own use & can only be withdrawn once for family use

  Public cord blood banks in India have limited inventory and not growing due to lack of financial aid. Further they charge upto ₹10 lakhs for release of a matching unit

  Increasing Success Rates with Cord Blood

  Success rates for cord blood transplants are improving with each passing year due to innovations such as:

  -Improved chemotherapy regimens that have led to lower transplant related mortality, lesser rejections, earlier patient discharge and lower complications

  -Multiplying the number of cord blood stem cells in the lab or supplementing them with other stem cell sources has shown to accelerate the time to immune recovery without increase in side effects

  Learn More

  Limited Indian-Origin Donors & Units

  Representation of adult donors of Indian origin is less than 1% in global registries, and size of Indian donor registries is significantly sub-optimal ( < 1 Million Donors) to provide reasonable access to a matching donor

  Inventory of cord blood units within public banks in India is still very small (< 10,000 units collectively)

• Results And Recommendations
  Understanding the specific cause of childhood-onset genetic conditions can enable faster treatment and help identify and improve potential treatment options.

  What Can The Test Tell You?

  GenomeScope Newborn collects data on 4000+ genes analyzes 1500 genes associated with childhood-onset conditions in infants below 24 months of age.

  Reports variants with a high correlation to the genetic condition.

  Outlines the conditions where early treatment can make a difference.

  Reports the conditions that have limited or no treatment options.

  What The Test Is Not About?

  It does not guarantee the lifelong validity of test results. Genetic testing may show some variations in the future with the discovery of new genetic mutations responsible for certain genetic conditions.

  The test results do not cover lifestyle diseases like blood pressure, cholesterol, adult disorders, etc.

  Carrier status for autosomal recessive genetic conditions is not reported in this test. Individuals may opt for knowing their carrier status after 18 years or older when they can make an informed decision regarding the implications of the test.

  A Positive Report:

  A disease-causing mutation has been identified.

  Test Results can highlight the probability of a variant/mutation to be:

  Disease-causing variant (Pathogenic) >99%.

  Increase the susceptibility/predisposition to a genetic condition (Likely pathogenic) between 90% - 99%.

  Detected but difficult to be classified based on currently available scientific evidence (Variant of Uncertain Significance or VUS) <90%.

  Note: The above differentiation is according to the ACMG variant differentiation guidelines.

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  Next Steps

  

  Speak To Our Genetic Counsellors Consult
  our genetic counselor to understand the test results better and plan for the possible treatment options accordingly.

  

  Consult A Physician
  Diagnosis of a genetic condition helps physicians move towards timely prevention, intervention, and management. It also allows planning for the possible treatment options specific to the baby’s unique health care needs.

  

  Possible Treatment Options Following Test Results:

  • Blood Stem Cell Transplant (49 medical conditions)
  • Medications
  • Surgery
  • Dietary Modifications

  A Negative Report

  It does not rule out the presence of a disease-causing variant as the test has a restricted gene panel specific to childhood-onset diseases. A physician may recommend further testing.

  It does not eliminate all chances of developing a genetic condition in the future. In case of future presentation of symptoms, Exome re-analysis aids in reclassification and understanding of the significance of the identified variant(s).

  We offer one free-of-cost re-analysis within a year from the baby’s birth, only including genes specific to symptoms of the disease.

  Data can be stored and retrieved for re-analysis up to 5 years after the test. A copy of the data is shared on a removable hard drive for an additional fee of `2,000.

• Collection Process
  • 1

    Collect

  • 2

    Fill Form

  • 3

    Dispatch

With Family Floater; your siblings, their spouses, as well as their children can enjoy the life-saving benefits of community banking and get access to the largest registry of Indian origin stem cells without needing to have a baby themselves.

• What’s Included?
  All LifeCell community banking members who wish to share the protection of community stem cell banking to their extended family’s health can now do so at a very affordable price and without necessarily needing to have made a personal contribution themselves to the community.

  Finding a Matched Unit

  LifeCell’s inventory of > 60,000 qualified units available for matching within the community registry is the largest in the country, thereby providing highest chances (>97%) of finding a suitably matched unit

  Free search for matching stem cells within LifeCell Community Inventory (StemMatch) & also within other registries worldwide.

  Learn More

  Release for Transplant

  With Family Floater, an unlimited number of matching units are also available for withdrawal by the parents’ siblings, (even siblings who have not yet planned a family) their spouse and grown up children (>2 years), 2 years post enrolment.

  Release is subject to usage in treatment of approved indications and registered clinical trials.

  Learn More

  Other Benefits

  Treatment for 82+ life-threatening disorders.

  Unlimited sample retrievals at no extra cost

  Free comprehensive pre-release testing & free worldwide shipment of matched units for transplant.

  Quality guarantee & disaster relief.

  Family Floater Tree

  Parents’ Siblings

  Their Spouses

  Their Children (>2 years)

• Why Choose Family Floater?
  It is a once in a lifetime chance for your extended family members to benefit from the opportunity of having access to a pristine and precious source of stem cells which has several advantages compared to other sources.

  Significant Need for Stem Cells

  Below is the risk of an individual being diagnosed of common blood cancers at some point in a lifetime*:

  • Leukemia: 1 in 62
  • Non-Hodgkin Lymphoma: 1 in 48
  • Myeloma: 1 in 125

  India has a high burden of inherited red cell diseases such as Thalassemia & Sickle Cell Disease (2.5 Lakh patients) where stem cell transplant is the only curative treatment option

  *As per National Cancer Institute, Surveillance, Epidemiology, and End Results Program

  Learn More

  Cord is Easier to Match

  For stem cell matching there are between 6-10 parameters that need to be matched, with each parameter having between 2000-4000 variants.

  Adult bone marrow requires 9-10 parameters to be matched.

  However Umbilical Cord Blood requires only 6-8 parameters to be matched thereby making it 10-100x more easier to find a match.

  Learn More

  Readily Available & No Additional Cost

  Umbilical Cord blood stem cells being frozen are 100% available and ready for immediate release. Further withdrawal of matching units from the community inventory is totally free.

  Even in advanced countries like the US about 50% of registered adult donors back out at the time of medical need. In some cases, since the donor is required to travel, there could be delays in access. Further there are significant costs in making arrangements for sourcing these cells.

  Recommended by Experts

  Community cord blood banking has the benefits of both private banking and public banking and hence is a superior option.

  No wonder it’s supported by leading medical experts unlike private banking which has been criticised- as inherited disorders make it unfit for baby’s own use & can only be withdrawn once for family use.

  Public cord blood banks in India have limited inventory and are not growing due to lack of financial aid. Further they charge upto ₹10 lakhs for releasing a matching unit.

  Increasing Success Rates with Cord Blood

  Success rates for cord blood transplants are improving with each passing year due to innovations such as:

  • Improved chemotherapy regimens that have led to lower transplant related mortality, lesser rejections, earlier patient discharge and lower complications
  • Multiplying the number of cord blood stem cells in the lab or supplementing them with other stem cell sources has shown to accelerate the time to immune recovery without increase in side effects

  Learn More

  Limited Indian-Origin Donors & Units

  Representation of adult donors of Indian origin is less than 1% in global registries, and size of Indian donor registries is significantly sub-optimal (<1 Million Donors) to provide reasonable access to a matching donor

  Inventory of cord blood units within public banks in India is still very small (<10,000 units collectively)

• Treatable Conditions
  Over 50,000 stem cell transplants occur worldwide each year for treatment of 90+ conditions approved currently, and the researchers are continuing to investigate its use in several more indications.

  Inherited Blood Disorders

  Acute Myelofibrosis

  Agnogenic Myeloid Metaplasia (Myelofibrosis)

  Amyloidosis

  Aplastic Anemia (Severe)

  Beta Thalassemia Major

  Blackfan-Diamond Anemia

  Congenital Amegakaryocytic Thrombocytopenia (CAT)

  Congenital Cytopenia

  Congenital Dyserythropoietic Anemia

  Dyskeratosis Congenita

  Essential Thrombocythemia

  Fanconi Anemia

  Glanzmann’s Thrombasthenia

  Myelodysplastic Syndrome

  Paroxysmal Nocturnal Hemoglobinuria (PNH)

  Polycythemia Vera

  Pure Red Cell Aplasia

  Refractory Anemia with Excess Blasts (RAEB)

  Refractory Anemia with Excess Blasts in Transition (RAEB-T)

  Refractory Anemia with Ringed Sideroblasts (RARS)

  Shwachman-Diamond Syndrome

  Sickle Cell Disease

  Inherited Immune Disorders

  Adenosine Deaminase Deficiency (SCID)

  Bare Lymphocyte Syndrome (SCID)

  Chediak-Higashi Syndrome (SCID)

  Chronic Granulomatous Disease

  Congenital Neutropenia

  DiGeorge Syndrome

  Evans Syndrome

  Fucosidosis

  Hemophagocytic Lymphohistiocytosis (HLH)

  Hemophagocytosis Langerhans’ Cell Histiocytosis (Histiocytosis X)

  IKK Gamma Deficiency (NEMO Deficiency)

  Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome

  Kostmann Syndrome (SCID)

  Myelokathexis

  Omenn Syndrome (SCID)

  Phosphorylase Deficiency (SCID)

  Purine Nucleoside (SCID)

  Reticular Dysgenesis (SCID)

  Severe Combined Immunodeficiency Diseases (SCID)

  Thymic Dysplasia

  Wiskott-Aldrich Syndrome

  X-linked Agammaglobulinemia

  X-Linked Hyper IgM Syndrome

  X-Linked Lymphoproliferative Disorder

  Inherited Errors in Metabolism

  Congenital Erythropoietic Porphyria (Gunther Disease)

  Gaucher Disease

  Hunter Syndrome (MPS-II)

  Hurler Syndrome (MPS-IH)

  Krabbe Disease

  Lesch-Nyhan Syndrome

  Mannosidosis

  Maroteaux-Lamy Syndrome (MPS-VI)

  Metachromatic Leukodystrophy

  Mucolipidosis II (I-cell Disease)

  Neuronal Ceroid Lipofuscinosis (Batten Disease)

  Niemann-Pick Disease

  Sandhoff Disease

  Sanfilippo Syndrome (MPS-III)

  Scheie Syndrome (MPS-IS)

  Sly Syndrome (MPS-VII)

  Tay Sachs

  Wolman Disease

  X-Linked Adrenoleukodystrophy

  Blood Cancers

  Acute Biphenotypic Leukemia

  Acute Lymphocytic Leukemia (ALL)

  Acute Myelogenous Leukemia (AML)

  Acute Undifferentiated Leukemia

  Adult T Cell Leukemia/Lymphoma

  Chronic Active Epstein Barr

  Chronic Lymphocytic Leukemia (CLL)

  Chronic Myelogenous Leukemia (CML)

  Chronic Myelomonocytic Leukemia (CMML)

  Juvenile Chronic Myelogenous Leukemia (JCML)

  Juvenile Myelomonocytic Leukemia (JMML)

  Myeloid/Natural Killer (NK) Cell

  PrecursorAcute Leukemia

  Non-Hodgkin’s Lymphoma

  Prolymphocytic Leukemia

  Leukocyte Adhesion Deficiency

  Rhabdomyosarcoma

  Thymoma (Thymic Carcinoma)

  Wilms Tumor